Endocrine Abstracts

Introduction: Amiodarone a potent antiarrhythmic medication induces thyroid dysfunction in about 20% of patients. Amiodarone-induced hypothyroidism (AIH) usually occurs early in the course of treatment, more often in iodine-sufficient areas, in women, and in the presence of thyroid autoantibodies. Long-term treatment with amiodarone is associated with a reduction in prevalence of AIH, which may reflect adaptation of the thyroid autoregulatory mechanisms to iodine excess.<p...

Amiodarone is a widely used antiarhrythmic agent. Although life-threatening side effects of amiodarone therapy are well known, it’s not always possible to replace it with dronedarone. Some clinical trials showed that treatment with dronedarone led to significantly more unfavourable end-points (e.g. in congestive heart failure). Therapy of amiodarone induced thyrotoxicosis still raises many questions concerning optimal treatment choice to achieve euthyreosis as soon as pos...